Wesker is extremely competitive and strives to become the best at every task he is given. The benefit of this cutthroat approach to life and work is that he will always give 100%, pushing himself to his physical or mental limits to overcome any task. However, Wesker’s overzealous ambition makes him insufferable to all but the most patient of companions, making it difficult to make friends while he either proves successful or utterly fails at being the best.

Wesker possesses a cold and completely uncaring demeanour. This will manifest itself in the fact that when push comes to shove,Wesker will just as soon leave a struggling ally behind rather than put themselves in danger. While this may ensure his survival, it often leaves him as an outcast amongst his peers.

Wesker is extremely cocksure and headstrong. Possessing a keen wit and exceptional level of intelligence, Wesker will often use his superior intellect to humiliate lesser minds. Basically, he is kind of a jerk, and that can sometimes get Wesker in a bit of trouble.

All who gain power are afraid to lose it, and Wesker is no exception. Some use their power for good, some for evil; Wesker, however, knows that these are just points of view. He is on a quest for greater power, and uses all his skills and abilities to ensure his supremacy, regardless of the consequences.

Through a mixture of cocksure courage and arrogant swagger, Wesker will not back down from a challenge when called out, even if the wiser path is to walk away or let it go. Wesker's personality does tend to rub a lot of people the wrong way, which generally puts him into situations that escalate quickly to violence. While he may not be the one to always start a fight, he will always see it through to it’s conclusion. Some have tried to play a challenge off as idle banter, but when Wesker initiates or accepts a challenge, he does not hold back.

Wesker seems to get his thrills, perhaps sadistic ones at that, from toying with his opponents. Some are content with simply striking down or injuring their opponent, but that is not enough for Wesker. No, he wishes to see his enemy descend into madness or kneel before him as a blathering mess; or even better, as a fresh new servant with a muddled mind. The Puppeteer usually forsakes outright hurting and maiming his opponent and focuses on illusions, mind tricks, and other wicked means of destroying a person.