Scalpel has been coated with a poison that can interfere with the body’s motor functions by targeting the muscles and nervous system. The affects can vary from the numbing, paralysis, or slowing of limbs to halting breathing and inducing seizures or sleep. The poison triggers on contact with the skin or bloodstream, with the most severe symptoms manifesting in the immediate area of the wound. Requires the "Poison Weapons Feat" on the Character Sheets to be effective in combat.

Scalpel has been fitted with a blade honed and sharpened to maximize cutting power, making it easier for Rhylance to push and cut directly into different materials that it comes in contact with. This perfectly straight, sharp blade, has limited friction on contact.

Due to his field of training, Rhylance has had his weapon customized to resemble a medical grade scalpel. The sleek design is a better fit for the medic.